Payment & Shipping Terms:
|Molecular Formula:||C21H30O3||Molecular Weight:||330.46|
|CAS Registry Number:||68-96-2||Assay:||99%|
|Mp:||276°C||Refractive Index:||90 ° (C=1, CHCl3)|
|Whatsapp:||0086 181 0845 9329|
17α-Hydroxyprogesterone Pharmacy Steroids CAS 68-96-2 17α-OHP
|Product Categories||Steroids;Biochemistry;Hydroxyketosteroids;Intermediates & Fine Chemicals;Pharmaceuticals;MIRADON|
|refractive index||90 ° (C=1, CHCl3)|
|storage temp.||-20℃ Freezer|
|Chemical Properties||White Solid|
|Usage||Progesteron. It was isolated from adrenal glands.|
|Usage||17α-Hydroxy Progesterone is a metabolite of Progesterone. It was isolated from adrenal glands.|
Generic Name: hydroxyprogesterone (hye-DROX-ee-proe-JES-ter-one)
Brand Name: Makena
17α-Hydroxyprogesterone (17α-OHP), or hydroxyprogesterone (OHP) (INN, BAN), also known as 17α-hydroxypregn-4-ene-3,20-dione, is an endogenous progestogen steroid hormone related to progesterone. It is also a chemical intermediate in the biosynthesis of many other endogenous steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids, as well as neurosteroids.
Under the brand name Gestageno, 17α-OHP has been marketed for clinical use in Argentina. However, esters of 17α-OHP, including hydroxyprogesterone caproate, as well as hydroxyprogesterone acetate and hydroxyprogesterone heptanoate to a much lesser extent, have been used far more widely in comparison, and when "hydroxyprogesterone" is referenced from the standpoint of medical use, what is usually being referred to is actually, in general, hydroxyprogesterone caproate.
17α-OHP is also the parent compound of a class of progestins referred to as the 17α-hydroxyprogesterone derivatives. Among others, this class of drugs includes chlormadinone acetate, cyproterone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, and megestrol acetate.
17α-OHP is derived from progesterone via 17α-hydroxylase (encoded by CYP17A1), or from 17α-hydroxypregnenolone via 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase.
17α-OHP increases in the third trimester of pregnancy primarily due to fetal adrenal production.
This steroid is primarily produced in the adrenal glands and to some degree in the gonads, specifically the corpus luteum of the ovary. Normal levels are 3-90 ng/dl in children, and in women, 20-100 ng/dl prior to ovulation, and 100-500 ng/dl during the luteal phase.
Hydroxyprogesterone is used for:
Reducing the risk of delivering a baby too early (preterm birth). Hydroxyprogesterone should only be used by women who are pregnant with one baby and have had a preterm delivery of one baby in the past.
Hydroxyprogesterone is a synthetic hormone (progestin). How it works to reduce the risk of recurrent preterm birth is not known.