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Pain Killer Local Anesthetic APIS Articaine hydrochloride/Articaine hcl 23964-57-0 with Delivery Guarantee for Sale/Email:email@example.com
Model NO.: B52
CAS No: 23964-57-0
HS Code: 3001200020
This drug was first synthesized by Rusching in 1969, and brought to the market in Germany by Hoechst AG, a life-sciences German company, under the brand name Ultracain. This drug was originally referred to as "carticaine" until 1984.
In 1983 it was brought into the North American market, to Canada, under the name Ultracaine for dental use, manufactured in Germany and distributed byHoechst-Marion-Roussel. This brand is currently manufactured in Germany bySanofi-Aventis and distributed in North America by Hansamed Limited (since 1999). After Ultracaine's patent protection expired, new generic versions arrived to the Canadian market: (in order of appearance) Septanest (Septodont), Astracaine, (originally by AstraZeneca and now a Dentsplyproduct), Zorcaine (Carestream Health/Kodak) and Orabloc (Pierrel).
It was approved by the FDA in April 2000, and became available in the United States of America two months later under the brand name Septocaine, ananesthetic/vasoconstrictor combination with Epinephrine 1:100,000 (trade nameSeptodont). Zorcaine became available there a few years later, also. Articadent (Dentsply) became available in the United States in October 2010. The three brands currently available in the United States are all manufactured for these companies by Novocol Pharmaceuticals Inc. (Canada). Ubistesin and Ubistesin Forte (3M ESPE) are also widely used in the United States and Europe. Orabloc (Pierrel) is aseptically manufactured and was approved by the FDA in 2010, became available in Canada in 2011, and in Europe from 2013.
Articaine is a local anaesthetic that has been approved overseas for several years. Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve. This action is prolonged by combining the drug with a vasoconstrictor.
The combination of articaine can be used for local or regional anaesthesia for dental procedures. Anaesthesia begins within six minutes and lasts for an hour. The half-life of articaine is approximately 1.8 hours. It is metabolised and then mainly excreted in the urine.
|Product Name||Foctory supply aarticaine hydrochloride|
|Synonyms||Articaine hydrochloride [USAN]; 2-Thiophenecarboxylic acid, 4-methyl-3-((1-oxo-2
-(propylamino)propyl)amino)-, methyl ester, monohydrochloride; 4-Methyl-3-(2-
(propylamino)propionamido)-2-thiophenecarboxylic acid methyl ester HCl; Articaine HCl; Articaine hydrochloride;
Carticaine hydrochloride; HOE 045; HOE 40045; Methyl 4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylate, monohydrochloride; Septanest; Septocaine; UNII-QS9014Q792; Ultracain; Ultracaine; 2-Thiophenecarboxylic acid, 4-methyl-3-(2-(propylamino)propionamido)-, methyl ester, monohydrochloride; Methyl 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-2-thenoate monohydrochloride; methyl 4-methyl-3-[(N-propylalanyl)amino]thiophene-2-carboxylate hydrochloride (1:1)
|CAS Registry Number||23964-57-0|
|Boiling point||440.6°C at 760 mmHg|
|Vapour Pressure||5.79E-08mmHg at 25°C|
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